Endocrine Abstracts

Our group has recently shown that interleukin-6 (IL-6) gene knockout mice develop mature onset obesity, and that IL-6 treatment enhances oxygen consumption in resting rodents via an effect on the CNS. Moreover, IL-6 is produced and released in large quantities from skeletal muscle during exercise. We have now investigated the effects of IL-6 deficiency during exercise in IL-6 gene knockout mice.Male 4-5 months-old IL-6 gene knockout mice on C57BL/6 background (n=6) and lit...